الفهرس | Only 14 pages are availabe for public view |
Abstract This is a retrospective and prospective study that aimed to predict fibrosis in HCV infected liver transplant recipients (25 recipients) with serum markers and TE( Fibroscan )and to validate the diagnostic accuracy of these noninvasive methods in comparison with liver biopsy. In our series none of the recipients who developed clinical HCV recurrence developed allograft cirrhosis over mean follow up period of 16.8 months and 92% of our patients developed only mild fibrosis (F1).Non invasive indices showed variable accuracy in prediction of fibrosis; Fib4 was not accurate in prediction of fibrosis while AST/ALT ratio and Age/Plt indices showed rough correlation with fibrosis stages assessed by Metavir score with no adequate results to conclude its ability to predict precisely each stage. APRI and Hyaluronic (HA) were able to predict fibrosis adequately in comparison with liver biopsy. Tissue elasticity was moderately able to predict fibrosis. Howevere large sample volume could help in proper validation as well as variability of stages of fibrosis among studied population |