الفهرس 
Serum microRNA-21(miR-21) as a diagnostic biomarker in human ovarian cancer and its relation with programmed cell death 4 (PDCD4) protein
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Abstract
Ovarian cancer is the third most common cancer of the female genital tract and the leading cause of cancer death associated with gynecologic tumors. MicroRNAs regulate at least 60% of human genes, including tumor suppressor genes and oncogenes and, thereby, can affect cancer risk. This study aims to study the relation between miR-21 and PDCD4, as one of its target proteins, to confirm the diagnostic role of Serum miR-21 as non-invasive biomarkers in human ovarian cancer in Egyptian females. Sixty newly diagnosed ovarian cancer cases and 30 apparently healthy females were recruited in this study. MiR-21 level was measured by TaqMan- Real time PCR assay and PDCD4 level was measured by ELISA. The findings of the present work showed significantly higher serum miR-21 levels and lower PDCD4 levels in ovarian cancer patients than in control group. In addition there was a statistically significant inverse correlation between miR-21 and PDCD4. Otherwise, the present findings did not show an association between miR-21 or PDCD4 with some of the clinico-pathological parameters examined in patients. Presence of significant influence of miR-21 on increased risk of ovarian cancer in the recruited group of patients. There is a significant inverse relation association between miR-21and PDCD