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العنوان
Design, preparation and evaluation of a certain phosphodiesterase (PDE5) inhibitor in solid dosage forms /
الناشر
Karim Aboubakr Mohamed Mohamed Soliman ,
المؤلف
Karim Aboubakr Mohamed Mohamed Soliman
هيئة الاعداد
باحث / Karim Aboubakr Mohamed Mohamed Soliman
مشرف / Mahmoud Mohammed Ghorab
مشرف / Howida Kamal Ibrahi
مشرف / Mahmoud Mohammed Ghorab
تاريخ النشر
2016
عدد الصفحات
288 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات
تاريخ الإجازة
6/8/2017
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Pharmaceutics
الفهرس
Only 14 pages are availabe for public view

from 333

from 333

Abstract

vanafil is an inhibitor of phosphodiesterase enzyme type 5 (PDE5). It was approved for treatment of erectile dysfunction by US Food and Drug Administration on April 2012, and by European Medicines Agency on June 2013. It is characterized by its rapid onset of action and it exhibits visual side effects to a lesser extent than other PDE5 inhibitors. It is poorly soluble in water and has relatively low bioavailability of 38%{u2013}41%. Its oral bioavailability could be increased by improving its aqueous solubility using different techniques. These include nanocrystallization, inclusion complexation and nanoemulsification