الفهرس 
Title : Evaluation of teratogenic effects of the muscle relaxant drug, myolgin, on albino rat fetuses
AbstractOnly 14 pages are availabe for public view
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Abstract
Teratology is the study of abnormal development in embryos, and the causes of congenital malformation or birth defects. Common musculoskeletal conditions causing tenderness and muscle spasms include fibromyalgia, tension headaches, myofascial pain syndrome, and mechanical low back or neck pain. Skeletal muscle relaxants are one of several classes of medications such as anti-inflammatory drugs and pain relievers that are used to treat these conditions. However insufficient information is available regarding its safety during pregnancy. Therefore, this work was initiated to study the effect of prenatal exposure of myolgin on fetuses of female rats. The study was conducted on pregnant rats to observe the safety profile of myolgin in comparison to control. Pregnant albino rats (Rattus norvegicus) were administrated during organogenesis period with therapeutic dose. Fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformation as well as histological study of liver, kidney and brain. Results showed significant reduction in placental weight of pregnant rats treated with myolgin. Fetal growth retardation. During gestational period was recorded also some skeletal anomalies were observed these abnormalities included weak ossification of the skull bones roof and bones formed girdles and limbs