الفهرس 
Title : The prognostic value of MSI, c-kit and lymph node microscopic metastases in stage II colorectal cancer
AbstractOnly 14 pages are availabe for public view
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Abstract
Background: Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. Clinicopathologic staging often does not provide sufficient prognostic information to determine which patients with stage II CRC have risk of recurrence sufficient to warrant adjuvant therapy. Strategies to improve prognostic assessment and to provide the ability to determine likelihood of response to therapies include development of molecular prognostic and predictive markers. Objective: The aim of this study is to evaluate the prognostic value of clinicopathological factors and certain molecular markers (MSI and c-kit) in stage II CRC. Patients and methods: The study included 60 patients with stage II CRC who underwent curative surgical resection and had available archival tumor tissue. C-kit was assessed by IHC while MSI was assessed by RT PCR. Results: Out of the 60 cases assessed, c-kit overexpression was found in 19 cases (33.3%) while MSI-H status was encountered in 29 cases (48.3%). In univariate analysis, performance status (PS), diabetes mellitus, family history of cancer and tumor (T) stage were significantly correlated with DFS while PS and T stage were significantly correlated with OS. C-kit over expression had no impact on either DFS or OS while low or stable MSI expression was associated with significantly better OS and DFS. In multivariate analysis, MSI was found to be independent prognostic factor for DFS and OS