الفهرس 
Title : The Role of the Toll-Like Receptor-9 Promoter Polymorphism (-1237T/C) in the Pathogenesis of chronic Kidney Disease in Egyptian Population
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Abstract
Chronic kidney disease (CKD) is increasingly recognized as a global public health problem due to its high prevalence, enormous cost of treatment and is associated with an increased morbidity and mortality, high risk of progression to end-stage renal disease (ESRD).As inflammatory processes and genetic factors are involved in the pathogenesis of CKD and end stage renal disease. Toll-like receptor 9 (TLR-9) a receptor for CpG DNA is involved in activation of immune cells in renal disease and may contribute to chronic inflammatory and disease progression. Objective: To Evaluate the Role of Toll-Like Receptor-9 Promoter Polymorphism c.-1237A>G in the pathogenesis of chronic kidney disease end stage kidney disease in Egyptian patients. Methods: Genotyping for Toll-Like Receptor-9 Promoter Polymorphism c.-1237A>G using Real-Time polymerase chain reaction by taqman probes were done a total of 200 persons, 85 patients had chronic kidney disease and 70 patients had end stage renal disease patients and 45 persons were apparently healthy used as controls. Results: Frequency of combined (AG&GG) mutant genotypes was significantly higher in ESRD patients and CKD patients as compared to control subjects where P value was <0.01. G allele (mutant allele) percentage was significantly increased in CKD and ESRD groups compared to control group (OR 2.486, 95% CI = 1.191{u2013} 5.190) and P value was <0.001. Which makes it as autosomal dominant risk factor in causing the renal disease. Conclusion: The results of this study suggest that, TLR9 c.-1237A>G gene polymorphism may have a role in pathogenesis of chronic kidney disease end stage renal disease in the Egyptian population.