الفهرس 
Title : Assessment of a panel of diabetes genes expression in type 2 diabetic patients
AbstractOnly 14 pages are availabe for public view
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Abstract
Up to 95% of all diabetes represents type 2 diabetes mellitus (T2DM). High morbidity and mortality rate is due to hyperglycemic direct and indirect effects on the vasculature resulting in multiple long-term microvascular complications. The emerging picture of genetics in T2DM involves risk susceptibility genes presumed to be implicated in T2DM pathogenesis and complications. KCNJ11 is KATP channel gene incorporated in cellular ion homeostasis and pancreatic beta cell insulin secretion. JAZF1 plays an important role in cell cycle regulation. WFS1 is implicated in pancreatic beta cell apoptosis via endoplasmic reticulum stress. PPARG is involved in insulin sensitivity. NOTCH2 is involved in normal pancreatic development and adult beta-cell survival of pancreas. EXOSC4 is related to cellular RNA processing and degradation. The present study aimed to investigate gene expression of (KCNJ11, JAZF1, WFS1, PPARG, NOTCH2 and EXOSC4) genes in peripheral blood of 100 subjects (30 non-complicated T2DM patients and 30 complicated T2DM patients versus 40 healthy controls) using quantitative Real Time PCR Array to identify genes that may be involved in T2DM pathogenesis and complications. Gene expression of KCNJ11, JAZF1, WFS1, and PPARG in complicated T2DM group was highly statistically significant lower than non-complicated T2DM group. Gene expression of NOTCH2 in complicated T2DM group was highly statistically significant higher than non-complicated T2DM group. Gene expression of EXOSC4 in complicated T2DM group showed no statistically significant difference compared to non-complicated T2DM group