الفهرس 
Title : Synthesis and biological evaluation of some novel benzofuran derivatives
ContentsOnly 14 pages are availabe for public view
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Abstract
Cancer, being the second cause of mortality in the world, and continuing to act as a major problem of health in both developing and developed countries. In the fight against cancer, recognition of novel potent, less toxic and selective anticancer agents remains one of the most vital health problems. Thus, in this study, thirty one new benzofuran derivatives were synthesized and tested for their in vitro cytotoxic activity against HCT116 colon cancer cell line. In vitro B-Raf inhibition in human colon cancer cell line HCT116 was also carried out for the most active 3 compounds. Fourteen derivatives were further tested against MCF-7 breast cancer cell line and in vitro EGFR inhibition in human breast cancer cell line MCF-7 was also carried out for the most active 3 compounds. Furthermore, docking studies were performed for the synthesized compounds in order to rationalize the obtained biological results as well as to help in understanding the various interactions between the ligands and enzymes active site (B-Raf and EGFR) to support the postulation that the active compounds may act on the same enzyme targets