الفهرس 
Title : Urinary Interleukin 22 Binding Protein as a marker of Lupus Nephritis in Egyptian children with juvenile systemic lupus erythematous.
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Abstract
Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune disease associated with formation of auto-antibodies. It was observed that Interleukin 22 binding protein (IL22BP) expression is dynamically regulated during infections and inflammatory conditions e.g. colitis. This study assesses its use as a marker of disease activity in lupus nephritis. This is a cross-sectional study conducted on 51 JSLE patients and 31 normal healthy controls. Urinary IL22BP was measured using ELISA technique and correlated with different clinical and laboratory data in systemic lupus as well as SLEDAI, renal SLEDAI and renal activity scores which were used to assess renal disease activity. Our results showed that urinary interleukin 22 binding protein levels are significantly higher in JSLE patients compared with controls; also it has positive correlation with activity scores so it can be used as a marker for disease activity in lupus nephritis patients