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العنوان
Lymphocyte mosiacisim in fanconi anemia :
الناشر
Lobna Assem Omar ,
المؤلف
Lobna Assem Omar
هيئة الاعداد
باحث / Lobna Assem Omar
مشرف / Hoda Mohamed Abd El-Ghany
مشرف / Ilham Youssry Ibrahim
مشرف / Rania Mohamed Sami
تاريخ النشر
2016
عدد الصفحات
163 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأحياء الدقيقة (الطبية)
تاريخ الإجازة
28/9/2016
مكان الإجازة
جامعة القاهرة - كلية الطب - Clinical and Chemical Pathology
الفهرس
Only 14 pages are availabe for public view

from 179

from 179

Abstract

Regarding chromosomal breakage test for the Fanconi group at 300nM Mitomycin C, the mean chromosomal breakage per cell was 4.67±1.58, the mean chromosomal breakage per aberrant cell was 5.6±1.1 and the mean chromosomal fragility index was 466.7±157 that significantly differed from non fanconi group (P=0.000). Fanconi anemia patients were further divided into: Classic Fanconi (CFA): no undamaged cells were left and most cells were in the category of 2{u2265} 10 breaks/cell3 and Fanconi with mosaicism (FA-Mo): two cell populations were distinguished at 300nM MMC, one behaving like typical FA cells, that was showing {u2265}10 breaks/cell, and one behaving like healthy controls, that was largely represented by the categories 0 ,1 and 2 breaks/cell