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العنوان
Abo incompatibility as a predictive marker in allogeneic peripheral blood stem cell transplantation from a fully matched sibling donor /
الناشر
Mai Abdelbassier Khalil Atya ,
المؤلف
Mai Abdelbassier Khalil Atya
هيئة الاعداد
باحث / Mai Abdelbassier Khalil Atya
مشرف / Hossam Mohamed Kamel
مشرف / Raafat Mohamed Abdelfattah
مشرف / Ahmed Magdy Rabea
تاريخ النشر
2017
عدد الصفحات
98 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأورام
تاريخ الإجازة
10/10/2017
مكان الإجازة
جامعة القاهرة - كلية الطب - Medical Oncology
الفهرس
Only 14 pages are availabe for public view

from 136

from 136

Abstract

Background: Hematopoietic stem cell transplantation is a curative procedure for various hematological cancers as well as benign diseases. HLA-typing is essential before transplantation for the success of the procedure, however, nearly more than one half of transplants involve recipient-donor ABO incompatibility with subsequent increased risk for hemolytic reactions, delayed engraftment and pure red cell aplasia. Objective: The objective of this study was to determine the effect of ABO incompatibility on the outcome of allogeneic stem cell transplantation including the incidence of hemolysis, frequency of blood transfusion, engraftment and hospital stay. Patients and methods: This retrospective study was conducted at the bone marrow transplant unit in Nasser Institute. The study included patients with hematological malignancies transplanted from a fully HLA- matched donor in the period from January 2008 till September 2016. Conclusions: In this study there was no significant statistical difference between the ABO compatible and incompatible groups regarding mortality, acute graft versus host disease, number of blood and platelet transfusion and hospital stay