الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Diazinon (DZN) is the most widely used organophosphorus (OP) insecticides, especially in developing countries. It is used to control the pests of agricultural crops in addition to control livestock pests; however it has deleterious effects on health for both humans and animals. Hepcidin is an iron-regulating peptide hormone, reflecting a likely role of hepcidin in innate immunity; hepcidin is also induced by inflammation. Thirty six male albino rats were classified randomly into six equal groups. group (G1) was kept as control, G2 and G3 were administrated a low and high dose of DZN as 17.5 and 35 mg/kg b.w. (1/20 and 1/10 LD₅₀) respectively, over period of 28 days (5 days/week). G4 received curcumin (CUR) as 200 mg/kg diet. G5 and G6 were administrated high and low dose of DZN, respectively and CUR. The obtained results revealed a significant increase in interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-Ü) as the proinflammatory cytokines, hepcidin and ferritin, decrease in erythropoietin (EPO), hemoglobin concentration (Hb), red blood cells (RBCs), serum iron and its related parameters in G2 and G3 were detected in comparison with untreated control (G1). Moreover, CUR treated groups (G5 and G6) revealed improvement of these parameters in comparison with those of corresponding groups. Significant decline in total protein (TP), total albumin (TAlb), total globulin (TGlb) together with albumin/globulin ratio (A/G) of G2 and G3 than control. Significant increase in liver, kidney and spleen malondialdehyde (MDA), catalase (CAT), nitric oxide (NO) with decrease in total antioxidant capacity (TAC) and glutathione (GSH) levels in G2 and G3 than control. Also, the obtained results revealed that there was a significant increase in liver and kideny function parameters in G2 and G3. As CUR is antioxidant and has antiinflammatory effect could rebalance the state of hypoprotenmia associated with hypoalbunemia, and attenuates the oxidative stress