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Abstract
Backgrounds: One of the metabolic effects of insulin deficiency is impairment of LPL which is a strictly insulin-dependent enzyme and this in turn increase the plasma level of serum triglycerides that usually normalize after establishing IV insulin. Methods:To asses the prevalence of hypertriglyceridemia at onset of DKA in T1DM patients and its relation to DKA severity and glycemic control we included 84 children with T1D presenting with DKA at the diabetes, endocrine and metabolism pediatric unit (DEMPU), children hospital, Cairo University during the period from January to August 2016. All patients fulfilling the inclusion criteria were evaluated for triglycerides level on admission and 48 hours after start of insulin therapy. HbA1c was also assessed 3 months later. Results:74 patients (88.1%) had hypertriglyceridemia at onset of DKA that resolved in 41 of them after 48 hrs, while 33 patients still had hypertriglyceridemia after 48 hrs. There was significant improvement in TG after 48 hrs of DKA management (p<0.001). When basal serum TG were correlated with other study parameters, a significant positive correlation was found with BG level (p=0.005) and a significant negative correlation was found with serum bicarbonate and GCS (i.e.conscious level) with a p value of 0.012 and 0.022 respectively. On the other hand, correlating TG after 48 hrs with different study parameters showed a significant positive correlation with BG level (p=0.005) and a significant negative correlation with pH, serum bicarbonate and GCS (p=0.01, 0.004 and 0.013 respectively). When insulin requirements and HbA1c were assessed 3 months later in the study group, no significant correlation was found between triglycerides (either basal or after 48 hrs of DKA) and glycemic control or insulin requirements TDD