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Abstract
Background: Cisplatin is a highly efficient antineoplastic drug. In spite of its major side effects, mainly nephrotoxicity, it is widely used in the treatment of many tumors, such as stomach, ovarian and lung cancers. Aim of the work: To study the possible protective effect of Moringa oleifera leaves extract (MOLE) on cisplatin induced nephrotoxicity in adult male albino rats. Materials and methods: Forty two adult male albino rats were divided into 5 groups: group I (control group), group II (Moringa oleifera group): received daily IP injection of MOLE 300 mg/kg for 2 weeks, group III (cisplatin group): Received a single IP injection of cisplatin 7mg/kg and left without further treatment, the animals were subdivided into 3 subgroups according to the time of sacrifice (after one week, 2 weeks and 4 weeks) to assess the spontaneous recovery. group (IV) treatment group received a single IP injection of cisplatin 7mg/kg followed by daily IP injection of MOLE 300 mg/kg for 2 weeks. Group(V) pretreatment group (prophylactic) received daily IP injection of MOLE 300 mg/kg for one week, before a single IP injection of cisplatin 7mg/kg followed by daily IP injection of MOLE 300 mg/kg for another 2 weeks. Results: Cisplatin treated group showed congested glomeruli, desquamation and loss of the epithelial lining cells of proximal and distal convoluted tubules and severe interstitial hemorrhage. Decreased area percent of PAS positive reaction and increased area percent of collagen fibers in Mallory{u2019}s trichrome stained sections. Moderate increased numbers of PCNA and CD34 immunopositive cells were observed. MOLE treated groups significantly improved these histological changes