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Abstract Summary and Conclusions White spot lesions are considered the earliest evidence of dental caries, which can be caused by an imbalance between demineralization and remineralization processes. As demineralization progresses, the intercrystalline spaces enlarge, and the lesion becomes more visible. This can be achieved through remineralization, to stop disease progression, and thus concomitantly improve aesthetics, as well as strength and function. This study aimed to evaluate the effect of two different commercially available remineralizing agents and a resin infiltrate on the surface composition as well as color change of artificially induced white spot enamel lesions. A demineralizing solution was applied to the tooth surfaces to create carieslike subsurface enamel lesions, with an intact surface, to simulate early enamel lesions. The results revealed a smooth enamel surface with few cracks before demineralization. However, after demineralization, irregular surface and dissolved prism cores, denoting surface dissolution were detected on the surfaces of artificial carious lesions. Both remineralizing agents, Curodont Repair and MI Paste Plus filled up defects and micropores on demineralized tooth structure. The results showed lower calcium and phosphorous levels for demineralized enamel surfaces, compared to a higher level in control enamel. Results also revealed an increase in Ca (27.6±0.3) and P (2 ± 0) percentage for Demineralized enamel treated with Curodont Repair. Higher carbon percentage was recorded in Control, and Demineralized enamel surfaces. It is worth mentioning that enamel surfaces treated by Icon and MI Paste Plus revealed a higher carbon percentage compared to Curodont Repair. Summary and Conclusions 61 Comparing different surface treatments, demineralized enamel revealed the highest significant color change values. All treatments of demineralized enamel significantly restored the tooth color, whereas ICON revealed the highest color difference values of all three treatments, followed by MI Paste Plus, then Curodont Repair which showed the lowest change in color (ΔE). The results revealed that demineralized enamel surfaces showed the highest color change values. |