الفهرس 
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Abstract
Primary immune thrombocytopenia (ITP) is an acquired immune-mediated disease characterized by isolated thrombocytopenia. Hypovitaminosis D is common in ITP, as in other autoimmune diseases.
Thus, vitamin D deficiency may have an important role in the pathogenesis of primary ITP, and vitamin D supplementation might reduce the risk of the disease by modulating the immune system.
The pathophysiology of ITP is heterogeneous and Several abnormalities involving the cellular mechanisms of immune modulation had been described. CD4&CD25 expression has a role in the pathogenesis of ITP.
We used flowcytometry to assess percentages of CD4 and CD25 cells as markers of regulatory T cells.
Vitamin D can affect the proliferation and function of human naturally occurring Treg cells.
The aim of this study was to explore the level of serum 25-hydroxyvitamin D and percentages of T-regulatory cells in peripheral blood of ITP patients to investigate their role in disease predisposing and severity also their prognostic impact in therapy.
Our results highlight the abnormalities of Treg cells in patients with ITP are significantly reduced .
This work demonstrates that decreased vitamin D in ITP patient Vitamin D supplements may be used as a therapy for ITP patient .
Because of the immune modulatory effects of vitamin D in ITP and the role of Treg cells in the pathogenesis of ITP we intend to study the association of both vitamin D level and T reg cells in ITP.
The results of the current study illustrated that significant decrease in serum vitamin D levels and CD4+ CD25+ T regulatory cells in ITP patients in comparison with healthy people but no correlation between level of serum 25-hydroxyvitamin D and percentages of T-Regulatory cells.
So, more studies with larger populations is highly recommended to assess the correlation between level of serum 25-hydroxyvitamin D and with percentages of T-Regulatory cells in peripheral blood of ITP and also their prognostic impact in therapy. Also, we recommended to use vitamin D as a routine investigation in ITP patients. Therefore, therapy with 25(OH) D could be a new option for treatment of ITP.