الفهرس 
Aim of the study
Optical coherence tomographyOnly 14 pages are availabe for public view
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Abstract
Thyroid eye disease (TED) is a complex orbital inflammatory disease, which can be sight threatening, debilitating and disfiguring. The acute progression of the disease is an ocular emergency, particularly optic nerve compression and corneal disease secondary to exposure. Most patients with TED have biochemical evidence of hyperthyroidism with the most common cause being Graves’ disease. A unique feature of TED in comparison to other autoimmune diseases is that it is self-limiting.
Optical coherence tomography (OCT) is an alternative and noninvasive test to evaluate the macula and the optic disc. OCT is a non- invasive, non-contact modality that has been used for measurement of peripapillary RNFL thickness and evaluation of macula.
The OCT measured RNFL thickness is not affected by corneal and lenticular birefringence. No additional reference plane is required to calculate RNFL thickness because Cirrus OCT provides an absolute cross-sectional measurement of retina from which RNFL thickness is calculated. An excellent intra-session and inter-session reproducibility of these measurements has been documented.
This study aimed to evaluate the macula and peri-papillary retinal nerve fiber layer (RNFL) in patients with auto-immune thyroid disease compared to normal individuals using spectral domain optical coherence tomography (OCT).
To elucidate our aim, a cross sectional study was conducted on 30 eyes of 15 patients with autoimmune thyroid disease who were diagnosed by the Department of Endocrinology, Menoufia University, Menoufia, Egypt,during from March 2020 till March 2021.
Summary
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People included in this study were divided into two groups as follow: group I (Cases group): included 30 eyes of 15 patients with autoimmune thyroid disease, and group II (Control group): included 30 eyes of 15 healthy volunteers who did not have any eye pathology, who had a 20/20 vision (corrected or uncorrected), and who were age- and sex-matched with the patient group.
Results of the current study could be summarized as follows:
There were no statistically significant differences between the studied groups regarding age and sex. The mean age of cases and control groups were (31.67±14.42 and 35.20±7.63), respectively. Also, most of them were females (93.33% and 80%).
Nasal retinal nerve fiber layers thickness was significantly increased among cases group (73.50±8.13) than control group (61.87±7.98).While, superior, inferior, and temporal did not show significant different between the studied groups.
Macular thickness parameters as (central, inner and outer rings) were significantly increased among patients with autoimmune thyroid disease than control group.
There were statistically significant negative correlations between age of studied patients with superior, temporal and nasal RNFL thickness and with inner ring temporal, and outer ring inferior macular thickness. While, the other RNFL and macular thickness parameters didn’t show any significant correlation with age among patients with autoimmune thyroid disease.
Superior RNFL thickness was significantly positive correlation with T3 and negative correlation with TSH. Also, inferior RNFL thickness was significantly positive correlation with T3 and negative correlation with free-4 among the studied patients with autoimmune thyroid disease.
Summary
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Macular thickness didn’t show any significant correlation with T3 and free-4 among the studied patients. While, macular thickness was significantly negative correlation with TSH and significantly positive correlation with TR-Ab among the studied patients with autoimmune thyroid disease.