الفهرس 
ANATOMY AND PHYSIOLOGY OF THE LACRIMAL GLAND AND LACRIMAL FUNCTIONAL UNITOnly 14 pages are availabe for public view
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Abstract
Objectives: To compare the effectiveness of non-preserved Dexamethasone 0.1%, non-preserved Dexamethasone 0.4% eye drops compared to preserved Dexamethasone 0.1% eye drops in addition to non-preserved artificial tears for idiopathic inflammatory punctal obstruction.
Patients and Methods: in a randomized clinical trial conducted 49 patients selected and randomly allocated into three treatment groups in a 1:1:1 ratio group (I) received non-preserved dexamethasone 0.1,group (II) received preserved dexamethasone 0.1, group (III) received non-preserved dexamethasone 0.4, Patient had been collected and recruited from ophthalmology department at faculty of medicine, Fayoum university and Fayoum insurance hospital, from 1st of September 2021 (for 12 months) till the 1st of September 2022. Slit lamp punctal staging and anterior segment OCT before, immediately after, and one month after stopping the treatment.
Results: There was a statistically significant improvement in symptom and slit lamp staging among (non-preserved dexamethasone 0.1% eye drops) and (non-preserved dexamethasone 0.4% eye drops) groups. While in (preserved dexamethasone 0.1% eye drops) group there were statistically non-significant improvement in the symptom and slit lamp staging score. The measured outer punctal diameter (OPD) by AS-OCT, OPD was increased significantly in (non-preserved dexamethasone 0.1% eye drops) and (non-preserved dexamethasone 0.4% eye drops) groups on post-treatment assessment as compared with pre-treatment assessment. While in (preserved dexamethasone 0.1% eye drops) group there was statistically non-significant improvement on post-treatment assessment as compared with pre-treatment assessment.
Conclusion: Dexamethasone (0.1% non-preserved, 0.4% non-preserved) showed an effective, symptom relieving and outer punctal diameter (OPD) improvement as compared with the 0.1% preserved dexamethasone, on the other hand, the 0.4% non-preserved dexamethasone carried more risk for increase the intra-ocular pressure (IOP).
Key Words: Idiopathic, Punctal Obstruction, epiphora, AS-OCT, outer punctal diameter (OPD).