الفهرس 
Chapter 1Only 14 pages are availabe for public view
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Abstract
The present study seeks to estimate the possible effect of the natural ethanolic extract of Physalis peruviana against neurotoxicity, reproductive toxicity and fetotoxicity induced by ZnO NPs in adult female rats with ZnO NPs. 110 healthy female rats were divided into 5 groups (G1, G2, G3, G4 and G5, n=22), each group was subdivided into 2 subgroups (SG 1a (n=18), SG 1b (n=4), SG 2a (n=18), SG 2b (n=4), SG 3a (n=18), SG 3b (n=4), SG 4a (n=18), SG 4b (n=4), SG 5a, and SG 5b (n=4), respectively). Females of SG 1a, SG 2a, SG 3a, SG 4a and SG 5a were used for neurotoxicological investigations, while females of SG 1b, SG 2b, SG 3b, SG 4b, and SG 5b were used for fetal investigations. The control G1 (Ctrl) were intraperitoneally injected with double distilled water 3 times/week for 4 weeks. Positive control G2 were treated with Physalis peruviana ethanolic extract (PPEE) (500 mg/kg bw) 3 times/week for 4 weeks. G3 were administered with ZnO NPs (5.6 mg/kg bw) 3 times/week for 4 weeks. G4 were received PPEE (500 mg/kg bw) an hour before injected with ZnO NPs (5.6 mg/kg bw) 3 times/week for 4 weeks. G5 were injected with ZnO NPs (5.6 mg/kg bw) 3 times/week for 4 weeks and after that treated with PPEE (500 mg/kg bw) for 7 consecutive days. After the experimental period, 9 females of SG 1a were sacrificed and blood was withdrawn to perform hormonal assays (FSH, LH, E2 and P4). Fresh brains and ovaries were collected and weighed. 5 fresh brains were homogenized for biochemical assays (TNF- α, Il- 6, serotonin, dopamine, SOD, CAT, GPx, GSH, MDA, NO, Zn content and total protein).