الفهرس 
Effect of SGLT2 inhibitor on Mean platelet volume and Platelet lymphocytic ratio in Diabetic patients with chronic coronary syndromes
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Abstract
Background: Mean platelet volume (MPV) is increased in patients with high
thrombogenic activation and also at risk for atherosclerosis. Platelets play an important
role in cardiovascular disease both in the pathogenesis of atherosclerosis and in the
development of acute thrombotic events.
Aim of the study: The study aims to assess effect of SGLT2 inhibitor on Mean platelet
volume and Platelet lymphocytic ratio in diabetic patients with chronic coronary
syndromes.
Patients and methods: 128 patients with type 2 DM. group A : received SGLT2
inhibitors and group B on oral anti diabetic treatment other than SGLT2 inhibitors .
Mean platelet volume and platelet lymphocytic ratio follow up after 6
th mounth of starting
the study .
Results: Patients were divided into two groups group A received SGLT2 inhibitors and
group B who on other oral anti diabetics treatment . We found that patients in group A
had significantly decrease in MPV compared to group B .
Conclusion: There was reduction in Mean MPV from 8.8 ± 1.14 to 8.28 ± 0.76 for
cases receives SGLT2 inhibitor with p value: 0.001 and There was reduction in Mean
HbA1C from 8.65 ± 1.2 to 7.92 ± 0.68 with p value: 0.001 for cases receives SGLT2
inhibitor