الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Management of the furcation defects through periodontal regeneration that involves restoration of the lost alveolar bone, cementum and periodontal ligaments is considered one of the most challenging missions in periodontal therapy.
Complementary and alternative medicine is nowadays our way to search for alternative natural products to overcome the limitations of most current bone grafting materials. Angelica sinensis, a well-known traditional Chinese herb, has been studied in many researches to investigate its various pharmacological effects. It has multiple biological activities as anti-inflammatory, anti-cancer, immunomodulatory, neuroprotective, anti-oxidative, anti-hepatotoxic and regenerative effects.
This study was conducted to evaluate the effectiveness of Angelica sinensis in conjunction with an osteoconductive bone graft material (β-TCP) on the periodontal tissue regeneration in the management of surgically induced class II furcation defects.
A randomized study design involved third and fourth lower premolars of 6 healthy mongrel dogs. 24 class II critical sized furcation defects were surgically created and managed as follows: 12 defects were treated with β-TCP only (control group) and the other 12 defects were treated with β-TCP and Angelica sinensis (experimental group). Dogs were sacrificed at 4 and 8weeks intervals. Jaw segments with the managed teeth were histologically processed for evaluation of the regenerative results. Image J software was used for quantitative analysis of 3 measured variables: percentage of formed bone surface area, thickness of formed bone trabeculae, and the height on the newly formed interradicular bone. Interpretation of alkaline phosphatase immunoreactivity was assessed through the intensity of the enzyme in the osteoblast cells.
The histomorphometric analysis showed a statistically significant increase in all the three variables measured at the 2 observational periods. The descriptive histological results showed the highly positive effects of Angelica sinensis on periodontal tissue regeneration including bone, cementum and periodontal ligaments. Also, the strongest expression of alkaline phosphatase activity in association with osteoblast cells was noticed in the defects treated with Angelica sinensis
Within the limitation of the present research; it could be concluded that Angelica sinensis is biocompatible material that enhances the osteoconductive effect of the bone grafts in the periodontal regenerative procedures.