الفهرس | Only 14 pages are availabe for public view |
Abstract Coronary artery disease is most commonly due to obstruction of the coronary arteries by an atheromatous plaque. The risk factors for atherothrombotic CAD are smoking, hypertension, Diabetes mellitus, dyslipidemia and obesity. The diagnostic investigation for obstructing coronary lesions is the coronary angiogram. Via iron-dependent enzymatic processes, iron has a pivotal role in maintaining the cellular function and integrity and mediates a variety of metabolic processes. However, careful homeostasis is also critical as both iron-deficient (e.g. skeletal muscle dysfunction) and overload (e.g.hemochromatosis) states can be deleterious to the human body. For the first time, (Sullivan., 1981) suggested time that iron stores in human body may be positively correlated with the risk of coronary heart disease. According to his hypothesis, production of free radicals that are subsequently modified to low density lipoprotein cholesterol (LDL) is important in the development of atherosclerosis and iron may stimulate the catalyzing of oxidation reactions that produce free radicals. |