الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Currently, the stage of severity of DN is determined according to the levels of albuminuria which lacks both sensitivity and specificity to detect early stage of DN. Furthermore, some DN patients with ESRD do not present with significant albuminuria. The lack of strong association between glomerular filtration rate (GFR) and albuminuria, in addition to the need for early diagnosis of DN to prevent its permanent damage are presenting a strong motivation to find an earlier and reliable marker to diagnose DN as an alternative to albuminuria based staging technique.
Urinary Cyclophilin A (CyPA) is an 18-kDa protein with ubiquitous characteristics. It is mostly distributed in the cytoplasm and facilitates protein folding and protein trafficking. It also acts as a cellular receptor for cyclosporine A .
Secreted CyPA (sCyPA) was reported to be correlated with cardiovascular disease (CVD), asthma, Rheumatoid Arthritis (RA), liver injury and inflammatory diseases. It was also detected in diabetic patients’ plasma and was shown to be secreted by monocytes in response to hyperglycemia.
In our study, we tried to investigate the association between Urinary CyPA and diabetic nephropathy in children with type 1 diabetes mellitus. The study was conducted from May 2021 till December 2021.
Sixty cases were recruited consecutively from children &adolescents