الفهرس | Only 14 pages are availabe for public view |
Abstract Mo) Molybdenum is the fourth member of the second transition series with an atomic number of 42. Molybdenum can enter the environment through releases from mining, milling, and smelting operations and coal-fired power plants. The primary source of molybdenum in air is from coal combustion. Mo is found at higher concentrations in leafy vegetables and legumes. Biologically, Mo belongs to the group of trace elements, i.e. the organism needs it only in minute amounts. If, however, an organism takes up too high amounts of Mo, toxicity symptoms are observed. Mo may enter the food chain with unforeseen consequences to the health of man and animals The aim of this study is to investigate the effects of molybdenum exposure on some hematological, biochemical parameters and histological changes in male rats. In this study 3groups (6 animals each) of male rats randomly for 6 weeks assigned and treated as following: group I (control) was orally carboxy methyl cellulose. group II was orally administered with a dose equal 33.3 mg/kg of body weight of ammonium molybdate, LD50 (333 mg/Kg/). group III was orally administered with a dose equal 66.6mg/kg of body weight of ammonium molybdate,LD50 (333mg/Kg). The obtained results revealed can be summarized as following: The present study revealed that there was no significant change in body weight, in all treated groups when compared to the control group. There were insignificantly changed in liver, brain, lung, heart and testes weight in all treated groups compared to control group. On the other hand, thyroid weight significantly increased in all treated groups compared to control group. The obtained revealed that RBCs, Ht, and WBCs significantly increased in in all treated groups when compared to the control group. Hb significantly increased in MoD1 and insignificantly changed in MoD2 when compared to the control group. Summary 104 The obtained results showed that treatment of rats with MoD1 and MoD2 significantly increased AST and AcP compared to control group. On the other hand rats treated with MoD2 significantly increased plasma ALT and ALT significantly decreased in MoD1 compared to control group. GT significantly decreased in both MoD1 and MoD2 treated groups compared to control group. It was found that plasma cholesterol and LDL-c, significantly increased in all treated groups compared to the control group. Amidopyrine N-demethylase, aniline 4-hydroxylase and NADPH cytochrome Creductase significantly incresead in liver in all treated groups compared to control group. Cytochrome P450 significantly decreased in liver compared to control group. Cytochrome b5 significantly decreased in MoD2 compared to the control group. On the other hand, cytochrome b5 insignificantly changed when rats treated with MoD1. Results showed that treatment of rats with MoD1 and MoD2 significantly increased plasma urea and creatinine in all treated groups compared to control group. GPx and GST significantly decreased in liver and brain when compared to control group. GSH significantly increased in liver in all treated groups compared to control group, in brain in MoD1and in testes in MoD2. Results showed that treatment of rats with MoD1 and MoD2 significantly decreased catalase in liver and brain. Results showed that rats treated with both MoD1 and MoD2 significantly increased TBARS in plasma and in liver in MoD2 compared to control group. Results showed that AChE in brain homogenate significantly decreased in MoD1 and MoD2 compared to control group. Histological examination of molybdenum showed bad effects on liver and testes compared to control group. Molybdenum toxicity can decrease cytochrome P450 in liver. Molecular studies are needed to be addressed |