الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Globally peptic ulcer disease is a severe public health issue caused by an imbalance between the defensive and aggressive mechanisms. In the current study, the phytochemical components of various organs (leaf, fruit, seed, and bark) of Jacaranda mimosifolia D. Don collected from Egypt at different seasons and geographical locations were investigated. UPLC-MS/MS allows a tentative identification of 53 compounds where flavonoids, quinoids, and triterpenoids represented the major identified classes. Multivariate statistical analyses (principal component analysis (PCA), hierarchical cluster analysis (HCA)-heat map and orthogonal projection to latent structures-discriminate analysis (OPLS-DA), and accompanied coefficient plots) was applied to investigate in-between and within-class discrimination of the different organs of Jacaranda mimosifolia D. Don. The obtained extracts were tested for their inhibitory activities against Helicobacter pylori Urease and human H+/K+-ATPase enzymes. Fruit extracts showed the highest inhibitory activity against H. pylori urease. Meanwhile, leaf extracts was found to be more potent, against human H+/K+-ATPase. The results of the biological activities were further modeled using Partial Least Squares Regression (PLSR) analysis together with the quantitative data.