الفهرس 
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Abstract
Obesity becomes a pandemic in recent years. Not only adults suffer from the disease, but increasing number of children and young people also become affected. One of the main causes of overweight and obesity is the excessive food intake; in particular heavily processed carbohydrates. The increasing prevalence of obesity is a considerable threat to public health, due to many comorbidities such as (type 2 diabetes mellitus, cardiovascular diseases and certain types of cancer). Obesity has many effects on multiple organs, including the salivary glands, bringing functional alterations with it. Among researchers, the relation between obesity and tooth decay, periodontal disease and xerostomia is being debated. More and more scientific reports draw attention to the changes in the microflora of the oral cavity during obesity, all changes are closely related to the morphological and functional alterations of the salivary glands. Aquaporin facilitates osmotic water transport across plasma membranes and thus transcellular fluid movement. The main role of salivary glands is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. The Aim of this study: 1-To evaluate the histopathological changes in parotid, submandibular and sublingual glands of high fat diet albino rat model. 2- To evaluate the immunohistochemical expression of AQP 8 in parotid, submandibular and sublingual glands of albino rats on basal diet and the changes occurring in high fat diet. Materials and methods: Twelve pathogen- free adult male Sprague-Dawley albino rats weighing 250-300 gm divided into 2 equal groups of 6 rats each: control group and high fat diet group. At the assigned time, Saliva was collected after intraperitoneal injection of pilocarpine, the rats were weighted, blood samples were collected from tail vein for assessment of blood glucose level, serum cholesterol, triglycerides, LDL and HDL then rats were decapitated under halothane anesthesia. The salivary glands (parotid, submandibular and sublingual) were dissected out and processed for histological and immunohistochemical studies. Results: Compared to the control group, high fat group releaved significant increase in body weight, blood insulin resistance, serum and saliva lipid profile in the form of increased triglyceride, cholesterol, LDL levels, while HDL was highly significantly decreased. Decreased expression of AQ8 which might contribute to salivary glands secretory dysfunction. Keywords: High fat diet, Salivary gland, Aquaporin 8.