الفهرس 
A pharmaceutical study on oral disintegrating tablets
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Abstract
Pioglitazone Hydrochloride (PGZ) is a is BCS class II antidiabetic drug that suffers
from poor aqueous solubility (0.015 mg/ ml in water) that causes a delayed onset of
action with a negative impact on its dissolution rate leading to subtherapeutic plasma
drug levels. It was chosen as a model drug for this study as there was no previous
published work for PGZ SNEDDS formulation solidified to produce an orally
disintegrating tablet (ODT).
Self-nanoemulsifying drug delivery systems (SNEDDS) are isotropic mixtures of oil,
surfactant, cosurfactant and drug, that spontaneously form thermodynamically stable
oil-in-water (o/w) emulsion once agitated with aqueous phase upon a low energy
requirement. It introduces the drug in a form of fine nanosized emulsion droplets,
less than 200 nm. thus, achieving a faster release all over the GI tract. Besides ease
of manufacture, maximized drug entrapment capacity and decreased cost of
production, being liquid in nature may limit the applications of SNEDDS as they
should be incorporated in soft/hard gelatin or HPMC capsules, which might be
associated with problems such as, incompatibility with capsule shell components,
formulation leakage and drug precipitation during manufacture or on storage at low
temperature. Accordingly, solidification of liquid SNEDDS was the proper solution
to overcome such limitations associated with SNEDDS. Production of solidified
SNEDDS powder (S-SNEDDS) using different adsorbents offered several
advantages, such as, high product stability, accurate dosing, better patient
compliance, flexibility for further dosage production.
However, another dosage form that became into research field interests was the
orally disintegrating tablets (ODT) with its various synonyms such as, fast
disintegrating tablets, quick dissolving tablets, orodispersible tablets, porous tablets
and rapimelts. The basic approach in the development of ODT is the distinctive use
of hydrophilic in nature, highly porous excipients in that can provide rapid
disintegration to present the drug as a solution or suspension form once placed in the
mouth. This in turn could be beneficial many patients who have difficulties to
administer conventional tablets such as, geriatric, bedridden, mentally retarded
nauseous or noncompliant patients, also travelling patients or those who have no
access to water.