الفهرس 
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Abstract
In intracytoplasmic sperm injection cycles, progesterone levels may rise in follicular phase on day of human chorionic gonadotropin (HCG) trigger.
Many studies analysed the impact of PE during the ICSI cycles with GnRH analogues, some of these observed negative effect on live birth and pregnancy rate, while others didn’t find any relationship.
Hence, the goal of this study was to evaluate the impact of increased serum progesterone levels at the time of HCG trigger on the outcome of fresh ICSI cycles.
This study was a retrospective case-control study that included 150 female patients who underwent fresh ICSI cycles. The data was collected from patients’ reports. The first group (cases group) consisted of 75 women undergoing ICSI complicated by premature luteinization during controlled ovarian stimulation (P ≥1.5 ng/ml). The controls were represented by 75 women undergoing ICSI not complicated by high progesterone levels at induction (P <1.5 ng/ml).
In the present study, the age in cases and controls ranged from 25 to 37 years with no statistically significant difference between both groups as regards age (30.51 ± 3.62 vs 30.76 ± 3.72 years, respectively, p= 0.673). The BMI of cases was statistically significantly lower than the controls (26.96 ± 4.38 vs 28.35 ± 3.94 kg/m2, respectively, p= 0.043).
Among cases, P4 on day of HCG injection ranged from 1.50 to 13.10 ng/mL with a mean ± SD of 3.98 ± 2.19 ng/mL. In comparison, P4 on the day of hCG administration ranged from 0.02 to 1.4 ng/mL with a mean ± SD of 0.64 ± 0.43 ng/mL in controls.
We found that women with positive pregnancy test among cases were more than those among controls (53.3% vs 49.3%, respectively) with no statistically significant difference between both groups regarding the results (p=0.624), indicating no significant effect of raised progesterone level at the time of HCG trigger on pregnancy rate.
In this work, Agonist protocol was performed on 25 women (33.3%) in the cases group and on 53 women (70.7%) in the control group. While the antagonist protocol was conducted on 50 women (66.7%) in the cases group and on 22 women (29.3%) in the control group. A high statisti