الفهرس 
Tissue resident memory T-cells (T ) in patients RM with psoriasis before and after treatment: (Prospective cohort study)
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Abstract
Psoriasis is a common chronic proliferative immune-mediated
inflammatory condition which is well known for its relapsing nature. r (TRM) are non-circulating memory T cells, the inappropriate activation of which can be
responsible for local recurrence of psoriatic lesions which have previously
disappeared after a successful therapy.
Objective: This work aimed at evaluating Tissue resident memory T cell
(CD103+, CD69+ and CD49a-) in psoriatic patients before and after treatment
with conventional, biological therapy and phototherapy.
Methods: One hundred and twenty psoriatic patients were included in this
cohort study after signing written informed consents. All participants were
subjected to full medical history taking, clinical examination, PASI scoring and
laboratory investigations. Patients were divided into 3 groups as; group A
(N=45) received conventional therapy (methotrexate, cyclosporine and
acitretin), group B (N=60) received biological therapy including anti TNF-α
(Infliximab, adalimumab and etanercept), anti-IL 17 (secukinumab), anti-IL-
12/23 (ustekinumab) and anti-IL-23 (guselkumab) and group C (N=15)
received phototherapy (nb-UVB) for 3 months. Two skin biopsies were taken
from the perilesional skin, one before starting treatment and the second 3
months after treatment.Tissue levels of (CD103, CD49a- amd CD69) TRM
markers were measured by flow cytometry technique.
Results: CD103 expression was significantly increased (P=0.01) in group A remained unchanged in the other groups.
CD49a- expression remained
unchanged within the 3 study groups. CD69 expression was significantly
II decreased in group B (P <0.001), significantly increased in group C (P =0,001)
and remained unchanged in group A.
Conclusion: Variable therapeutic modalities for psoriasis exert variable effects on TRM, None of the studied therapeutic modalities was capable of totally eliminating TRM in the studied patients