الفهرس 
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Abstract
Atopic Dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense pruritus, highly variable and chronic skin lesions with typical localization. To date the pathogenesis of pruritus in AD is not fully understood, but recent studies have established a role of interleukin 31 (IL-31) as a potential mediator for pruritus induction. Pruritus, being a hallmark of this condition, is responsible for much of the disease burden.
The aim of our study was to evaluate the interleukin 31 levels in atopic dermatitis patients and its relation to disease severity. We included 30 patients who were assessed clinically for the severity of disease using the SCORAD score. Their blood samples were taken for assessment of the serum interleukin 31 levels. 17 patients were male and 13 patients were female. Majority of the patients, 25, had mild to moderately severe disease. The data collected was then analyzed using SPSS version 20.
We found that the patient group had a significantly elevated serum interleukin 31 level as compared to the control group. However there was no significant relation between serum IL-31 levels and severity of the disease.
With regards to ADCT and interleukin 31 levels, we did not find any significant relationship. However we found a significant correlation between ADCT and SCORAD scores.
In our study, we also found a significant relation between IL-31 levels and associated allergic conditions, moreover, there was also a correlation between the disease severity and associated allergic conditions, especially conjunctivitis and allergic rhinitis. There was no significant correlation between IL-31 and gender or age.