الفهرس 
SPINAL ANESTHESIAOnly 14 pages are availabe for public view
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Abstract
Single Shot Spinal anesthesia (SSSA) is associated with considerable perioperative shivering and can be challenging to treat. Some pharmacologic agents like N-methyl d-aspartate receptor antagonists, magnesium sulfate and opioid analgesics have been used for restriction of post-spinal anesthesia shivering. Besides that shivering is poorly understood, the gold standard for the treatment and prevention has not been defined yet.
This study aimed to compare between the prophylactic intravenous administrations of acetaminophen vs dexamethasone vs pethidine regarding the incidence of shivering induced by single shot spinal anesthesia in the orthopedic surgeries of the lower limbs.
The study included 108 patients fulfilling the inclusion criteria undergoing orthopedic surgeries of the lower limbs. The patients were randomized into three equal groups by a computer-generated table of random numbers, each included 36 patients, namely groups A, B, and C according to the drug used as an anti-shivering agent.
group A: 36 patients received 0.5 mg/kg Pethidine IVI.
group B: 36 patients received 15 mg/kg Acetaminophen IVI.
group C: 36 patients received 0.1 mg/kg Dexamethasone IVI.
Regarding the BSAS score, in group A, 3 patients (8.3 %) developed moderate shivering (Grade 2). In group B, 5 patients (13.9 %) developed moderate shivering as well as 7 patients
(19.4 %) developed severe shivering. In group C, 5 patients
(13.9 %) manifested moderate shivering, as well as 7 patients (19.4 %) suffered from severe shivering. A statistically significant difference existed between the groups of P-value 0.02.
Our study revealed that acetaminophen was more effective than dexamethasone, while pethidine was the most effective in decreasing the incidence of PSAS