الفهرس 
Interaction between environmental factors and geneticsOnly 14 pages are availabe for public view
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Abstract
Background and Aim: Psoriasis is a chronic debilitating disease
affecting 1-2% of the whole population. It is characterized by recurrent
episodes of red, scaly, raised skin plaques that develop within normal skin
and is triggered by a large number of factors, such as drugs, stress, physical
injury to the skin and infection. Our aim was to examine the expression
levels of LncRNA NEAT-1 in the plasma of psoriasis patients and its role in
pathogenesis of the disease and if it can be used as a potential marker for the
diagnosis of psoriasis.
Subject and Methods: This study was performed in Medical
Biochemistry and Molecular Biology Department, Faculty of Medicine,
Fayoum University. After the approval of ethical committee, 60 subjects
from Dermatology outpatient clinic, Faculty of Medicine, Fayoum
University Hospital were recruited for the study and divided into 2 groups;
40 psoriatic patients and 20 age and sex matched healthy subjects. Serum
was separated for detection of LncRNA NEAT-1 expressions by real time
RT-PCR.
Results: The results revealed a significant increase in the expression
of NEAT-1 in serum of psoriatic patients than controls.
Conclusion: This study highlights the contribution of NEAT-1 in
the pathogenesis of psoriasis.