الفهرس 
Association between urinary bisphenol a leveland polycystic ovary syndrome
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Abstract
More than 10 % of women worldwide are diagnosed with polycystic ovary syndrome (PCOS). It isthe most common cause of female reproductive and metabolic dysfunction.BisphenolA(BPA) is an organic compound that is widely used in the production of plastic substances.BPA is thought toplay a role in the pathogenesis of many diseases, including PCOS.
AIM:This work aimed to study the association between urinary BPA level and PCOS in Egyptian females.
SUBJECTS & METHODS:The current study included 120 female subjects, 60 patients diagnosed with PCOS based onModified Rotterdam’s Criteria and 60 healthy controls.
All included females were subjected to full history taking, clinical examination andpelvi-abdominal ultrasound examination.Panel of laboratory assay includedFSH, LH, fasting blood glucose, fasting insulin level, HOMA-IR, DHEAs and free testosterone. Urinary BPA was assayed for all subjects using HPLC in-house method.
RESULTS:Body mass index was significantly higher in PCOS than control group(p value <0.01).Regarding laboratory findings, LH, LH/FSH ratio, HOMA-IR, DHEAs and free testosterone all showed significantly higher levels in PCOS compared to healthy controls. Urinary BPA was significantly higher in PCOS than control group whether adjusted to urinary creatinineor not with p values0.04 and 0.017 respectively.
CONCLUSION AND RECOMMENDATIONS:Urinary BPA was higher in PCOS cases, making it more likely associated with the occurrence of the disease and it might have a role in the pathogenesis of PCOS. It is recommended to increase awareness about possible health hazards of BPA.