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Abstract
Thesis title: Evaluation the influence of Artemisia herba-alba extract on
pancreas and liver of diabetic male rats
Candidate: Ahmed Fathy Hassan Mohammed
Diabetes mellitus (DM) is a common worldwide chronic disease
affecting the liver. DM induced chronic complication in different
organs especially the liver and pancreas. Artemisia herba-alba (AHA),
is commonly used as therapeutic plant against several chronic diseases.
The present study aimed to investigate the oral hypoglycaemic activity
of AHA extract in streptozotocin (STZ)-induced diabetic male albino
rats and investigating its underlying oxidative stress, hepatocytes
apoptosis and liver fibrosis mechanism, as well as to evaluate the
antibacterial activities against six multidrug-resistant (MDR)
pathogenic bacterial species. 60 Adult male albino rats randomly
divided into 4 groups each 15: group 1; control, group 2; STZ induced
diabetes, group 3; were given AHA (50 mg/kg body weight) and later
injected intraperitoneally with a single dose of STZ, group 4; diabetic
rats treated by AHA (50 mg/kg body weight) orally for 21 days. rats
were sacrificed at the end of the experiment, Blood glucose, C-peptide,
serum insulin, α-l-fucosidase (AFU), alanine aminotransferase (ALT),
aspartate aminotransferase (AST), and total antioxidant capacity (TAC)
were evaluated.