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Abstract There are four main types of recurrent breast cancer: local, regional second primary and metastatic. Local recurrent breast cancer may be after BCT in the preserved breast tissue or after MRM in the skin along the scar of the previous operation or in the subcutaneous or in the soft tissues on the chest wall. Regional recurrent breast cancer is recurrence that occurred in the regional lymph nodes as ipsilateral axillary lymph nodes, supraclavicular lymph nodes, infraclavicular lymph nodes and internal mammary lymph nodes. While a mastectomy is the surgical standard of care for most patients with a local recurrence following breast-conserving therapy (BCT), repeat breast excision may be feasible for select patients who request breast conservation. This prospective study included 100 female patients with recurrent breast cancer after conservative surgery. The study was done at the general surgery department, Menoufia university hospital in the period starting from February 2020 to December 2022. Our study is to outline management strategy for locoregional recurrent breast cancer after conservative therapy. Surgical management: for cases presented with IBTR after BCS (88 cases) was either complete mastectomy surgery was done to 61 cases, wide local excision was done to 27 cases. Systemic therapy was done as following: Targeted therapy was done to 18 cases, and hormonal treatment were done to 61 cases. from the results of this study, we found that the main management strategy of LRR breast cancer after conservative therapy was surgical interference with local or locoregional recurrence followed by hormonal or target therapy. While with regional recurrence, axillary LN dissection had limited role in management. |