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العنوان
Comparing serum pentraxin 3 in diabetic patients with and without retinopathy/
المؤلف
Mostafa, Soad Zakaria Mohammed.
هيئة الاعداد
باحث / سعاد زكريا محمد مصطفى
مشرف / يحيى مصطفى غانم
مشرف / طلعت عبد الفتاح عبد العاطى
مشرف / محمد عبد الرؤوف قرنى
الموضوع
Diabetes. Internal Medicine.
تاريخ النشر
2023.
عدد الصفحات
49 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب
تاريخ الإجازة
15/4/2023
مكان الإجازة
جامعة الاسكندريه - كلية الطب - Internal Medicine
الفهرس
Only 14 pages are availabe for public view

from 63

from 63

Abstract

A class of metabolic diseases known as diabetes are defined by hyperglycemia initiated by deficiencies in insulin action, secretion or both. Long-term complications of diabetes include the potential loss of vision, retinopathy, nephropathy, peripheral neuropathy, atherosclerotic cardiovascular disease, peripheral arterial disease, and cerebrovascular disease.
A notable diseased vascular consequence of diabetes is diabetic retinopathy, which also happens to be the most common cause of blindness in those who are at employed age.
‏ Long-term diabetes, poorly controlled blood sugar, high blood pressure , the presence of dyslipidemia and diabetic nephropathy are all common risk factors for the development of diabetic retinopathy. ‏
serum amyloid P and C-reactive protein (CRP) are parts of the pentraxin 3 (PTX3), a recognised member of the pentraxin superfamily. Unlike CRP, which is made by the liver, PTX3 is made by a range of cell types and tissues—most notably the vasculature—in response to inflammatory stimuli. (61)
PTX3 may act as a biomarker of inflammation by reflecting the local inflammatory condition in tissues.
The aim of the work is to compare serum pentraxin 3 in diabetic patients who have and who do not have retinopathy.
This study included 81 diabetics. All patients were subdivided into group A (41 Diabetics with retinopathy) and group B (40 Diabetics without retinopathy).
The subjects underwent a thorough clinical examination, which included a general examination and an ophthalmological examination.
Laboratory investigations including fasting blood glucose, HbA1C, Albumin to creatinine ratio, Lipid profile and Serum pentraxin 3 using Human Pentraxin 3 (PTX3) ELISA Kit (96T) were measured.
The study’s findings showed that:
• In this study, group A