الفهرس | Only 14 pages are availabe for public view |
Abstract To date, pre-transfusion compatibility tests performed, in Blood Banks, are still based on the interaction between antigen and antibody and subsequent agglutination of red blood cells. Tests that identify the antibody indicate the probable specificity of the antibody, but whether an antibody will destroy red blood cells bearing the corresponding antigen depends on various conditions. Thus, the concept of compatibility encompasses much more than cross matching. Particularly, when it comes to PLT transfusion therapy we are dealing with issues arising from the fact that PLTs contain both significant amounts of ABO antigen on their surface, as well as anti-ABO alloisogglutinins in the donor’s plasma. Although relatively rare, intravascular (acute intravascular haemolytic transfusion reactions) AHTRs have been caused by ABO antibodies after the transfusion of Platelets, across a minor ABO incompatibility. |