الفهرس 
Introduction
Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study is a descriptive case control study conducted on 90 subjects (60 patients diagnosed with RA, 15 patients diagnosed with other arthritis and 15 age and sex matched controls). Patients were recruited from the Rheumatology Department , Assiut Universty Hospitals, in the period from January 2020 up to December 2021and the study was done in the Clinical Pathology Department of Assiut University.The aim of the present study was to highlight the role of CTHRCI biomarker in diagnosis of RA, to correlate CTHRC1 level with other biomarkers used in diagnosis of RA and to assess its value in diagnosis of seronegative patients The following laboratory investigations were done Complete blood count (CBC) using Ruby CELL-DYNESR using westergren tubeRF using Rapid latex slide agglutination test. CRP using Rapid latex slide agglutination test Anti-CCP using ARCHITECT I system CTHRC1 using Human collagen triple helix repeat-containing protein 1 ELISA kit. Catalog No: SG-12024 purchased from SinoGeneClon Biotech Co.,Chin The study revealed that the mean age of the studied RA patients was 44.02 ± 8.65 (range; 25 – 65) years old, with a female sex predominance (female to male ratio of 5.7:1) Patients with RA have significantly higher ESR (mm/h), CRP (mg/l), RF (IU/l) and anti-CCP (IU/l) compared to other arthritis patients and matched controls While regarding to the studied CTHRC1 biomarker it was significantly higher in studied RA patients compared to other arthritis patients and matched controls.the serum CTHRC1 level was significantly increased in patients with high disease activity compared to those with low or moderate disease activity as assessed by DAS28 score.