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Abstract Fish aquaculture offers a high potential for food security and income generation in developing countries. Therefore, hypoxia has been studied as one of the factors affecting fish aquaculture. Oreochromis niloticus was chosen for being a successful candidate species in fish aquaculture and for rapid growth to full size, rich in protein and minerals, within six months, as well as the fish’s ability to face most of the environmental conditions. Hypoxia is one of the most important factors affecting fish aquaculture in general and fish farms in particular. There are many causes of hypoxia, including climate change, high stocking density, excessive growth of aquatic plants and algae, as well as environmental pollutants. Thus, this study aimed to observe the effect of hypoxia and reoxygenation on antioxidant enzymes and growth performance in Oreochromis niloticus. |