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Abstract Drug abuse loads a burden to the patients and their families. Cannabis and synthetic cannabinoids abuse contribute to 3–5% of the world population drug abuse. Many literatures have concluded the increased incidence of psychosis proneness associated with synthetic cannabinoids over natural cannabis. This is a cross-sectional analytical, observational, case-control, comparative study. This study aimed tocompare psychosis proneness in patients with cannabis dependence and synthetic cannabinoids dependence and assessingthe relation between the severity of use of cannabis and synthetic cannabinoids and development of any psychotic features. The study is divided into two parts 1) The theoretical part: It included the review of literature divided into the following chapters: Chapter one:cannabis and synthetic cannabinoids. In this chapter, pharmacology, pharmacodynamics and pharmacokinetics of cannabis and synthetic cannabinoidshave been reviewed. As well, cannabinoid receptors and endogenous cannabinoid agents have been also discussed. Furthermore in this chapter we discussed the physiological and psychological effects of both cannabis and synthetic cannabinoids. Chapter two: psychosis proneness. In this chapter psychosis proneness definition was established in addition to its psychometric assessment including schizotypal personality questionnaire. As well, prevalence of psychosis, pathophysiology of psychosis and the relation between cannabis and SCs and psychosis has been reviewed. |