الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 125 |  |  |
| | | from | 125 | | |
Abstract
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia due to defects in insulin secretion and/or action. The worldwide burden of DM and its complications are presently in an increase. Ejaculatory dysfunction is one of the most common male sexual disorders. The spectrum of ejaculatory dysfunction extends from premature ejaculation, through delayed ejaculation to a complete inability to ejaculate (known as an-ejaculation), and includes retrograde ejaculation. DM is usually associated with long-term dysfunction of blood vessels, nerves, and several organs including the epididymis, vas deferens (VD), SV, prostate, and urethra. Although both diabetes patients and their physicians are increasingly aware of diabetic ejaculatory dysfunction, this awareness still lags behind that of other diabetes complications. The problems linked to the ejaculatory dysfunction may extend beyond the poor quality of life in diabetics. The Aim of this study: To evaluate the frequency of ejaculatory disorders in Egyptian diabetic patients. This study was carried on two groups. • Diabetic group included 100 patients . • non-diabetic group including 100 age matched subjects. They recruited from the outpatient clinic of Andrology unit in Dermatology and Andrology & STDs Dep., Mansoura University Hospital for management of infertility after IRB approval with code number (MS.18.05.163) It was conducted over a period of 12 months. • All the included cases were subjected to full history taking, full general, genital examination stressing on hypo-gonadal symptoms and biochemical investigations such as fasting blood sugar, post prandial blood sugar, HBA1c, serum prolactin, serum testosterone. Results of the study: The mean value of BMI was 29.12and 27.88 in diabetic and non-diabetic groups respectively with statistically significant high BMI in diabetic group. There was statistically significant higher HbA1c in diabetic group 7.68±1.31 as compared to 5.06±0.44 in non-diabetic group. There was statistically significant abnormal urine analysis among diabetic group. There was a statistically significant higher ejaculatory disorders among diabetic group. Most common ejaculatory disorders among diabetic group was premature ejaculation (50%) and retrograde ejaculation (17%). There was statistically significant higher HbA1c in diabetics with ejaculatory disorders. HbA1c was 7.89±1.36 as compared to 7.19±1.03 in diabetics without ejaculatory disorders. There was a statistically significant abnormal urine analysis associated with ejaculatory disorders representing 24.4% as compared to 0% in non-ejaculatory disorder group. There was statistically significant negative correlation between duration of DM and testosterone level (r=-0.248, p=0.013). Increased duration of DM was associated with decreased testosterone level. There was a statistically significant positive correlation between duration of EjD and age (r=0.291, p=0.014), HbA1c (r=0.238, p=0.046), FBs (r=0.306, p=0.009) and PPs (r=0.257, p=0.031). Increased duration of ED was associated with increased age, HbA1c, FBs and PPs. There was a statistically significant negative correlation between duration of EjD and testosterone level (r=-0.266, p=0.025). Increased duration of EjD was associated with decreased testosterone level. Conclusion: It was concluded that: Ejaculatory dysfunction encompasses several disorders related to DM and its complications. The most common ejaculatory disorders among diabetic group was premature ejaculation (50%) and retrograde ejaculation (17%). There was a statistically significant higher HbA1c in diabetics with ejaculatory disorders. There was a statistically significant positive correlation between duration of ejaculatory disorders and age & HbA1c. Recommendations All ejaculatory disorders should be looked for thoroughly during the clinical evaluation of diabetic men. Further studies on this subject with larger samples size are required to help explanation of this relationship. Further studies should be done for studying the effect of diabetic control on ejaculatory disorders improvement.