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Abstract
Introduction: The aim of this study was to investigate the association between GHR gene mutation in Exon 10 and Craniofacial morphology in Egyptian subjects The study was conducted to investigate the association between SNPs; C422F, P477T, I526L and P561T with craniofacial morphology.. Materials and Methods: The present study was conducted to investigate the association between SNPs; C422F, P477T, I526L and P561T with craniofacial morphology. Thirty eight adults were recruited from the department of Orthodontics, Faculty of Oral and Dental Medicine Cairo University. The patients were examined clinically and based on their facial profile cephalogram was performed. All participants were Egyptian with full permanent dentition and under active orthodontic treatment. Exclusion criteria entail any developmental anomalies as clefts or syndromes involving craniofacial disfigurements and previous history of orthognathic surgery and or growth modification therapy.After completion of the cephalograms; cephalometric landmarks were located. Manual tracing of the cephalometry was performed including 6 angular and 5 linear measurements. Two ml venous blood was collected from each patient for DNA extraction