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Abstract
Fowl Cholera, Infectious Coryza and ORT are important respiratory diseases affecting chickens industry. So, our study was planned to prepare and evaluate the protective efficacy of an inactivated polyvalent vaccine containing Pasteurella Multocida serotypes (A5,A8,A9&D2), Avibacterium paragallinarum serotypes(A&C) and Ornithobacterium Rhinotracheale serotype (A) adjuvanted with Montanid ISA70 in comparison to monovalent commercial Fowl Cholera and monovalent commercial Infectious Coryza vaccine. The prepared vaccine was safe producing no adverse side effects. The immunizing efficacy of these vaccines was evaluated in SPF chickens, which were immunized at 6 weeks of age. The developed humoral immune responses against the antigenic content of these vaccines were monitored using ELISA test. Also the protective efficacy of these vaccines was determined using challenge test. It was concluded from the obtained results that the combined prepared polyvalent activated vaccine adjuvanted with mantanid ISA70 stimulates higher immune response and protection efficacy as compared with the local commercial monovalent Fowl Cholera and Infectious Coryza vaccine adjuvanted with liquid paraffin. Thus this vaccine can be considered as a strong approach to the control of respiratory infections caused by these pathogens in chickens