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Abstract
Head and neck cancer (HNC) is the 6th most common cancer worldwide and the incidence of head and neck squamous cell carcinoma (HNSCC) has increased over the last 30 years. Approximately one-third of patients present with early-stage disease while the majority of present with locally advanced stage disease. Radical treatment in this situation requires multimodality therapy with surgery, commonly followed by postoperative radiotherapy or chemo radiotherapy, or organ preserving primary radiotherapy, with or without chemotherapy, with reduced cosmetic compromise. As accelerated repopulation of tumor cells during radiotherapy is as an important cause of treatment failure in cancers of the head and neck, efforts have been made to reduce the overall treatment time of radiation and in several retrospective reviews the importance of overall treatment time in achieving optimal local tumor control have demonstrated