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Abstract
Genuphil is the joint care formula that contains the essential components responsible for maintaining the normal structure of the articular cartilage and synovial fluid of the joints & reduces the pain and inflammation associated with these conditions. Genuphil is a mixture of Glucosamine Sulfate, Chondroitin Sulfate and Methyl Sulfonyl Methane (MSM). The aim of this study was to evaluate the teratogenic effects of Genuphil on pregnant rats and their fetuses. Pregnant albino rats (Rattus norvegicus) were administrated daily oral doses 120, 240 mg/kg of Genuphil from the 5th day of gestation till the end of lactation (20th day of lactation). The animals were sacrificed at the end of gestation and during lactation. Fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformation as well as histological study of liver, kidney and brain. Results showed decreased weight gain of pregnant rats and increased abortion rate of pregnant rats treated with Genuphil (120, 240 mg/kg). Fetal growth retardation during gestational and lactational period was dose and time dependent. Hematomas and anomalies of limbs (Brachydactyly, shortness, contraction and absence of limbs) were noticed morphologically in the fetuses of the treated groups