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Abstract
Breast cancer is a global urgent public health problem, and is particularly crucial to Egypt as it is the most common female malignancy, with most cases manifesting axillary lymph node metastasis about 70% at the time of diagnosis. The invasive properties of breast cancer in Egyptian patients is strongly associated with low survival rate and may exhibit specific 2molecular feature3 that could be attributed to genetic factors and environmental exposure. BRCA1 gene mutations have been shown to predispose to familial BC, but its{u2019} relevance to sporadic BC hasn{u2019}t been thoroughly investigated, even though sporadic BC represents more than 90% of breast cancers. Very few studies have been carried out to look into the molecular profile of BRCA1 in Egypt, especially in non familial breast cancer cases. Thus, the aim of our study was to screen mutations in the largest exon of BRCA1, exon 11, in female Egyptian patients with sporadic breast cancer. 30 female breast cancer patients and 14 healthy individuals were enrolled in our study. Amplification of exon 11 from tissue samples and direct sequencing was performed.