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Abstract
This thesis introduces Synthesis of new derivatives of dispiropyrrolidinyl oxindole 6a-j and dispiropyrrolizinyl oxindole 8a-j through 1,3-dipolar cycloaddition reaction of azomethine ylides generated from isatin, sarcosine/ L-proline through decarboxylative route with dipolarophile 4a-j. All the newly synthesized compounds were evaluated for their antimicrobial activities and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested compounds displayed excellent activity against all the tested microorganisms