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Abstract
Background: Eczematous dermatitis including atopic dermatitis (AD) and allergic contact dermatitis (ACD) are characterized by T-cell infiltration into the dermis & epidermis. Although the effector pathways of activated T-cells have been intensively studied, the active role of epidermal keratinocytes (KC) in induction and maintenance of eczematous dermatitis has been rather neglected. It has been suggested that apoptosis of KC induced by T-cells and mediated by CD95 is crucial event in the transition from activation of the immune system to the manifestation of eczematous dermatitis. Objectives: The aim of this study is to assess the expression of Fas receptor (Fas-R) in the skin of eczematous dermatitis to help for the study of T-cell mediated KC apoptosis that might help for the future use of anti-apoptotic therapy for prevention and treatment of eczematous dermatitis