الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Chronic kidney disease (CKD) is a global public health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic stem cells mobilization by granulocyte-colony stimulating factor (G-CSF) on adriamycin (ADR)-induced chronic renal diseasein rats. Thirty albino rats were classified into three groups: control, ADR group: rats received single intravenous injection of ADR(5mg/kg) and G-CSF group: rats received ADR by the same route and the same dose asthe previous group then G-CSF (70æg/kg/day) two hours after ADR injectionthen daily for 5 consecutive days. At time of sacrifice (after 6 weeks), blood samples were taken toestimate blood urea nitrogen (BUN) &serum creatinine. Kidneys sections were stained with H&E, Masson{u2019}s trichrome, PAS stains&Immunohistochemichal staining against CD34 & caspase-3. G-CSF treated group exhibited protection against renal injury manifested by reducing blood urea nitrogenand serum creatinine levels,improving histological architecture and increasing theproliferative capacity of renal tubule