الفهرس Only 14 pages are availabe for public view
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Abstract
Introduction: Mechanical dyssynchrony, which is incoordinate wall motion of different ventricular segments in systole and diastole is an important contributor to left ventricular (LV) dysfunction in cardiomyopathy Therefore, the evaluation of mechanical dyssynchrony may be important as part of the assessment of ventricular function in children with heart failure. Echocardiography is the preferred and most common method to evaluate for the presence of mechanical dyssynchrony. Aim: The aim of this study was to detect the possibility of mechanical dyssynchrony in children of dilated cardiomyopathy using conventional echocardiography, Tissue Doppler Imaging, and 2D speckle tracking and to evaluate effect of mechanical dyssynchrony on myocardial systolic and diastolic functions. Methods: This study was conducted on 35 patients of dilated cardiomyopathy following at Cardiomyopathy Outpatient Clinic in Cairo University Specialized Pediatric Hospital. Thirty-two age, sex and body surface area matched were selected as controls. All patients were subjected to history taking, clinical examination and full echocardiographic examination using Conventional echo, TDI, 2D-STE, MPI of left and right ventricles, global longitudinal strain, circumferential strain and radial strain ,time to peak longitudinal strain, circumferential strain and radial strain, basal, apical rotation and torsion of left ventricle, TAPSE and MAPSE. Results:, There was LV systolic dysfunction as FS, EF, S” " ~ " ” LV, MAPSE and IVA in cases of dilated cardiomyopathy with p <0.0001 also, All types of strain are affected with p <0.0001. The LV diastolic function assessed by conventional and TDI as evident by decreased E velocity, DT , average E” " ~ " ” , E’/A’ ratio of septum and lateral wall seems to be affected in cases of dilated cardiomyopathy with p <0.0001. There was RV systolic dysfunction as evident by decreased TAPSE, S” " ~ " ” RV and diastolic dysfunction documented by reduced tricuspid E’/A’ ratio and E” " ~ " ” velocity